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. Author manuscript; available in PMC: 2015 Dec 1.
Published in final edited form as: Neuromuscul Disord. 2014 Aug 7;24(12):1063–1067. doi: 10.1016/j.nmd.2014.07.006

Figure 1.

Figure 1

Muscle biopsy sections taken from left biceps. (a) Hematoxylin and eosin staining show marked variation in fiber size. Groups of atrophic fibers (arrowheads) surround large fibers (asterisk). Characteristic rimmed vacuoles are denoted by arrows. Fibrosis is seen in scattered areas (double arrows). (b) Hematoxylin and eosin and (c) modified Gomori trichrome serial sections demonstrating rimmed vacuoles (arrows) in both atrophic and non-atrophic fibers. (d) Fibers with rimmed vacuoles (arrows) stain intensely with acid phosphatase, indicating increased lysosomal activity.