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. Author manuscript; available in PMC: 2016 Jan 1.
Published in final edited form as: Biochim Biophys Acta. 2014 Oct 23;1848(1 0 0):159–166. doi: 10.1016/j.bbamem.2014.10.022

Figure 1.

Figure 1

Lipid lining amino acids in MscS. A) The positions of the previously identified closed state lipid interacting residues (red, L35, I39, L42, N50, I78, L82) and the newly identified open state lipid lining residues are shown (blue, V29, V32, A36, V40, I44, M47, A51, N53, L55, S58) on the closed [2], open (2VV5, [10]), and desensitized (2OAU, [13, 14]) structures of MscS. I43, which is lipid exposed in both the open and closed state of MscS, is shown in purple. B) A side view of the open state crystal structure (2VV5, [10]) showing the lipid interacting residues. The approximate location of the lipid bilayer is shown as a dashed line.

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