Table 2.
Adjusted models of regular aspirin use among adults not clinically indicated for aspirin therapy for primary cardiovascular disease prevention (n=16,922)
| Predictors | Aspirin usea (regular vs nonregular)
|
|
|---|---|---|
| Fully adjusted model | Reduced model | |
| Age (years) | ||
| 40–49 vs 30–39 | 2.35 (1.94, 2.84) P<0.001 |
2.37 (1.96, 2.86) P<0.001 |
| 50–59 vs 30–39 | 7.07 (5.84, 8.56) P<0.001 |
7.18 (5.96, 8.64) P<0.001 |
| 60–69 vs 30–39 | 16.05 (13.31, 19.36) P<0.001 |
16.16 (13.47, 19.37) P<0.001 |
| 70–79 vs 30–39 | 29.79 (24.18, 36.68) P<0.001 |
29.21 (23.98, 35.58) P<0.001 |
| Sex | ||
| Female vs male | 0.66 (0.57, 0.75) P<0.001 |
0.65 (0.57, 0.74) P<0.001 |
| Race/ethnicity | ||
| Non-White, non-Hispanic vs White, non-Hispanic | 1.00 (0.69, 1.44) P=0.999 |
– |
| Hispanic vs White, non-Hispanic | 1.04 (0.72, 1.48) P=0.853 |
|
| Unknown vs White, non-Hispanic | 1.08 (0.74, 1.56) P=0.658 |
|
| Health insurance | ||
| Public assisted vs commercial | 0.94 (0.83, 1.01) P=0.086 |
– |
| None vs commercial | 0.92 (0.69, 1.27) P=0.688 |
|
| MESA region | ||
| Central vs north | 0.72 (0.66, 0.80) P<0.001 |
0.73 (0.67, 0.80) P<0.001 |
| Ambulatory visits in past 3 years | ||
| 5–8 vs 1–4 | 1.36 (1.19, 1.55) P<0.001 |
1.35 (1.18, 1.54) P<0.001 |
| 9–14 vs 1–4 | 1.69 (1.48, 1.93) P<0.001 |
1.68 (1.47, 1.91) P<0.001 |
| ≥15 vs 1–4 | 2.11 (1.85, 2.41) P<0.001 |
2.08 (1.83, 2.36) P<0.001 |
| Smoking | ||
| Current vs former or never | 1.00 (0.87, 1.14) P=0.964 |
– |
| Body mass index | ||
| Overweight vs healthy weight | 1.19 (1.05, 1.34) P=0.005 |
1.21 (1.08, 1.36) P=0.001 |
| Obese vs healthy weight | 1.26 (1.11, 1.42) P<0.001 |
1.30 (1.16, 1.46) P<0.001 |
| Severely obese vs healthy weight | 1.57 (1.33, 1.87) P<0.001 |
1.64 (1.39, 1.93) P<0.001 |
| Systolic blood pressure (mmHg) | 1.00 (1.00, 1.01) P=0.076 |
– |
| Total cholesterol (mg/dL) | 1.00 (1.00, 1.00) P=0.915 |
– |
| HDL cholesterol (mg/dL) | 1.00 (0.99, 1.00) P=0.320 |
– |
Notes:
a
Values are reported as odds ratio (95% confidence interval) of regular aspirin use. Values greater than 1.00 indicate that, relative to the reference category (or a 1-unit increase for continuous predictors), the odds of regular aspirin use increased. – indicates variables not included in the reduced model.
Abbreviations: MESA, Marshfield Epidemiologic Study Area; HDL, high-density lipoprotein; vs, versus.