Table 2.
Association between dietary inflammation index (DII) score and risk of colorectal cancer in the Bellvitge Colorectal Cancer Study
| Cutoff | Colorectal cancer | Colon cancer | Rectal cancer | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Cases | OR (95 % CI)a | OR (95 % CI)b | Cases | OR (95 % CI)a | OR (95 % CI)b | Cases | OR (95 % CI)a | OR (95 % CI)b | ||
| Q1 | <−0.73 | 112 | 1 | 1 | 66 | 1 | 1 | 46 | 1 | 1 |
| Q2 | −0.73 to 1.06 | 81 | 0.89 (0.59–1.35) | 0.96 (0.63–1.48) | 55 | 1.09 (0.68–1.76) | 1.25 (0.76–2.06) | 26 | 0.65 (0.37–1.16) | 0.71 (0.39–1.29) |
| Q3 | 1.07–3.05 | 114 | 1.44 (0.95–2.16) | 1.51 (0.99–2.31) | 66 | 1.47 (0.91–2.37) | 1.58 (0.96–2.59) | 48 | 1.36 (0.81–2.29) | 1.48 (0.85–2.55) |
| Q4 | >3.05 | 117 | 1.66 (1.08–2.56) | 1.65 (1.05–2.60) | 78 | 2.02 (1.23–3.33) | 2.24 (1.33–3.77) | 39 | 1.20 (0.67–2.14) | 1.12 (0.61–2.06) |
| P trend | 0.008 | 0.011 | 0.004 | 0.002 | 0.25 | 0.37 | ||||
| Continuous (1 DII unit) | 424 | 1.08 (1.02–1.15) | 1.08 (1.01–1.15) | 265 | 1.10 (1.03–1.19) | 1.12 (1.04–1.21) | 159 | 1.04 (0.96–1.13) | 1.03 (0.95–1.12) | |
aModel 1 was adjusted for sex, age, and total energy intake
bModel 2 was additionally adjusted for body mass index, first-degree family history of colorectal cancer, physical activity, tobacco consumption, and medication use (aspirin and nonsteroidal anti-inflammatory drug)