Table 2.
Brain catecholamine levels (pg/mg of wet weight) and ratios in Mo-dp heterozygotes compared to WT females
| Mouse ID |
Atp7a genotype |
DOPA | DOPAC | DA | NE* | DHPG* | DOPAC: DHPG* |
DA: NE* |
|---|---|---|---|---|---|---|---|---|
| 117B | +/− | 3.9 | 156.5 | 1131.4 | 127 | 6.7 | 23.4 | 8.9 |
| 180 | +/− | 9.2 | 178 | 1239.5 | 121.4 | 7.1 | 25.1 | 10.2 |
| 203 | +/− | 7.3 | 111.2 | 1191.6 | 187.6 | 7.7 | 14.4 | 6.4 |
| 318 | +/− | 10.4 | 146.4 | 834.7 | 213.3 | 8.5 | 17.2 | 3.9 |
| Mean | 7.7 | 148 | 1099.3 | 162.3 | 7.5 | 20.0 | 7.3 | |
| SEM | ±1.4 | ±13.9 | ±90.9 | ±22.7 | ±0.4 | ±2.5 | ±1.4 | |
| 117 | +/+ | 10.8 | 144.9 | 1217 | 339.7 | 19.6 | 7.4 | 3.6 |
| 178 | +/+ | 13.2 | 121.8 | 998.9 | 257.2 | 18.3 | 6.7 | 3.9 |
| 179 | +/+ | 6.1 | 117.9 | 1129.5 | 350 | 18.1 | 6.5 | 3.2 |
| 319 | +/+ | 8.6 | 100.1 | 757.5 | 376.9 | 18.4 | 5.4 | 2 |
| Mean | 9.7 | 121.2 | 1025.7 | 331 | 18.6 | 6.5 | 3.2 | |
| SEM | ±1.5 | ±9.2 | ±100 | ±25.8 | ±0.3 | ±0.4 | ±0.4 | |
| P-value | 0.378 | 0.159 | 0.606 | 0.003 | <0.0001 | 0.002 | 0.029 | |
*
Statistically significant
SEM: standard error of the mean