Table 2.
PAN-related proteins.
(A) The proteins listed show similar domain organization as PAN-family proteins, but contain a different effector domain (e.g. CARD). (B) PAN-related proteins are listed, which contain an effector domain unrelated to the death domain fold. Note that only the dendritic cell specific CIITA encodes a CARD. Activation (↑, +); Inhibition (↓, −); both is reported (+/−).
| A. Related death domain fold proteins: | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Name | Synonym | Chromosome | Effector Domain | LRRs | Length (kDa) | Ligand | Apoptosis | Inflammation Immunity | Inducer |
| Apaf1 | 12q23 | CARD | 12–13 WD40 | 130 | cytochrome c | + | p53↑ | ||
| Nod1 | CARD4 | 7p14.3 | CARD | 11 | 108 | iE-DAP | + | + | (Salmonellae, Staphylococcus, IFNγ)↑ |
| Nod2 | CARD15 | 16q12.1 | CARD, CARD | 12 | 115 | MDP | +/− | (IFNγ, TNFα, Salmonellae, Staphylococcus)↑ | |
| IPAF | CLAN, CARD12 | 2p22.3 | CARD | 14 | 116 | PGN, LTA, LPS | + | + | (p53, LPS, TNFα)↑ |
| CIITA | 16p13.13 | AD | 4 | 124 | + | IFNg↑ | |||
| B. Related non death domain fold proteins: | ||||||||
|---|---|---|---|---|---|---|---|---|
| Name | Synonym | Chromosome | Effector Domain | LRRs | Ligand | Apoptosis | Inflammation Immunity | Inducer |
| NAIP | BIRC1 | 5q13.2 | BIR, BIR, BIR | 14 | - | + | ||
| TLR1-11 | TIR | PAMPs | + | + | inflammation | |||
| Resistance (R) proteins | TIR, CC | PAMPs | + | |||||