Table 4. Oxidative stress markers in kidney, plasma and urine (n=7) (n=21).
| Variables |
Groups |
Pa | |||||
|---|---|---|---|---|---|---|---|
|
C |
HD+S |
HD+S+L |
|||||
| Mean | s.e. | Mean | s.e. | Mean | s.e. | ||
| Kidney | |||||||
| TAP (% g−1 protein) | 54.6 | 3.8 | 59.3 | 2.4 | 59.4 | 3.4 | 0.243 |
| Plasma | |||||||
| TAP (%) | 40.4 | 3.1 | 42.6 | 4.4 | 49.3 | 3.5 | 0.498 |
| Urine | |||||||
| MDA (μM) | 2.17a | 0.67 | 5.6b | 0.55 | 4.08a,b | 0.60 | 0.003 |
| AGEs (μg ml−1) | 0.21a | 0.004 | 0.24b | 0.006 | 0.24b | 0.006 | 0.005 |
| 8-OHdG (ng ml−1) | 7.91a | 0.54 | 12.24b | 0.58 | 12.92b | 0.44 | <0.001 |
Abbreviations: AGE, advanced glycation end products; C, control; HD+S, animals subjected to diet-induced obesity; HD+S+L, HD+S supplemented with lycopene; MDA, malondialdehyde; 8-OHdG, 8-hydroxy-deoxy-guanosine; TAP, total antioxidant performance.
Mean values with unlike superscript letters were significantly different (P<0.05).
One-way analysis of variance with Holm–Sidak post-hoc test.