Table 2. Substrates, substrate affinities and tissue distribution of SCL5 genes and the respective SGLT/SMIT transporter.
| Gene (transporter) | Substrate | Apparent affinity, K0.5 (mM) | Tissue expression |
|---|---|---|---|
| SLC5A1 (hSGLT1) | D-Glucose | 0.5 | Intestine, trachea, kidney, heart, brain, testis and prostate |
| D-Galactose | 1 | ||
| SLC5A2 (hSGLT2) | D-Glucose | 5 | Kidney, brain, liver, thyroid, muscle and heart |
| D-Galactose | >100 | ||
| SLC5A3 (cSMIT1) | Myo-inositol | 0.050 | Brain, heart, kidney and lung |
| D-Glucose | >50 | ||
| SLC5A4 (hSGLT3) | D-Glucose, Miglitol | 19, 0.003 | Brain, intestine, kidney, lung, muscle, testis and uterus |
| SLC5A9 (hSGLT4) | D-Glucose, D-Mannose | 7.7, 0.15 | Intestine, kidney liver, brain, lung, trachea, uterus and pancreas |
| SLC5A10 (hSGLT5) | D-Glucose, D-Galactose | Not known | Kidney |
| SLC5A11 (rtSMIT2, rtSGLT6) | Myo-inositol | 0.27 | Brain, kidney and intestine |
| D-Glucose | 36 |
Abbreviations: c, canine; h, human; rt, rat.
Substrate specificity, apparent affinity (K0.5 for the substrates) and tissue distribution according to (16;17;40–47).