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Hypothetical model of familial adenomatous polyposis molecular cascade. APC: Adenomatous polyposis coli; FAP: Familial adenomatous polyposis; CRC: Colorectal cancer; KRAS: Kirsten rat sarcoma viral oncogene homolog; Smad4-SMA: (Small) and MAD (mothers against decapentaplegic) related protein 4.
