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. 2014 Nov 3;3(11):e125. doi: 10.1038/oncsis.2014.38

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Copyright © 2014 Macmillan Publishers Limited

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/

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Lack of CD4+ T cells in sh C/EBPβ tumor-bearing mice attenuates the effect of C/EBPβ on tumor growth and metastasis formation. (a) 4T1 tumor growth (non-treated sh C/EBPβ, anti-CD3-treated sh C/EBPβ, anti-CD4-treated sh C/EBPβ) in BALB/c mice (n=8 mice per group). (b) Number of CTCs in the blood (left panel) and bone marrow (right panel) of tumor-bearing mice. (c) Tumor volume in nude mice 14 days after implantation (left panel) and percentage of nude tumor-bearing mice developing lung metastasis (right panel). (d) Human breast cancer tissue stained for MHCII (DAB) and C/EBPβ (Alexa 594).