Figure 1.

Clinical Features of Individuals 1 and 7

(A and B) Clinical photographs of individual 1 performed at the age of 6 days showing severe micrognathia, a short neck, and low set and dysplastic ears.

(C and D) Hand radiographs of individual 1 at the age of 6 days showing the Manzke dysostosis.

(E and F) Hand radiographs of individual 7 performed at the age of 28 years showing bilateral radial deviation and clinodactyly of the second digit. On the right hand a triangular-shaped bone is inserted between the second metacarpal and its proximal phalanx, and on the left hand the accessory bone and proximal phalanx fused.