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. 2014 Nov 4;4(11):e477. doi: 10.1038/tp.2014.114

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Copyright © 2014 Macmillan Publishers Limited

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/

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Proteins identified in the three iTRAQ experiments from two studies (Sydney Delirium Study and Edinburgh Delirium Study), and a total of 17 subjects with either mild or moderate-to-severe delirium are shown. All proteins were identified with a confidence of 95% or greater (unused score of ⩾1.3 in ProteinPilot v3.0), were based on 4–7 iTRAQ technical replicates and significantly dysregulated proteins were identified at the P⩾0.05 level. (a) Total numbers of unique proteins identified in any of the three experiments, proteins identified in all three experiments and numbers of dysregulated proteins identified in 1–3, 4–7 or ⩾8 subjects are shown. (b) Percentage of proteins identified in all three experiments and dysregulated in 1–3, 4–7 or ⩾8 subjects. The list of proteins dysregulated in eight or more delirium subjects, and which are identified in all three iTRAQ experiments are shown in Table 2.