Table 1. Pathway analyses of significantly altered metabolites (PLS-DA VIP⩾1.0, SAM, FDR⩽0.10, SAM q⩽0.1) 2 and 14 h after a single injection of Ketamine (3 mg kg^-1).

Pathway	P-value	PHolm-corrected value	FDR	Metabolite	Time point (h)
Citrate cycle	0.000012	0.00095	0.0006	Fumarate	2
				Succinate	2
				Thiamine pyrophosphate	2
				Phosphoenolpyruvate	2
				Acetyl-CoA	2
				Malate	2 /14
Glycine, serine and threonine metabolism	0.000016	0.00127	0.0006	Glyoxylate	2
				Betaine aldehyde	2
				Betaine	2
				Choline	2
				Glycerate	2
				Serine	2
				Cystathionine	2
				3-Phosphoglycerate	2
Pyrimidine metabolism	0.000855	0.06841	0.0234	Ureidosuccinate	2
				Cytidine	2
				Thymidine	2
				Uridine	2
				Uridine 5'-monophosphate (UMP)	2
				Cytidine diphosphate (CDP)	2
				Methylmalonate	2
Pentose phosphate pathway	0.000004	0.00036	0.0004	Glucose-6-phosphate	14
				6-Phospho-D-gluconate	14
				Fructose-6-phosphate	14
				Fructose-1,6-bisphosphate	14
				Erythrose-4-phosphate	14
Glycolysis/gluconeogenesis	0.000432	0.03501	0.0177	Fructose-6-phosphate	14
				Fructose-1,6-bisphosphate	14
				Glucose-6-phosphate	14
				Dihydroxy-acetone-phosphate	14
				Glyceraldehdye-3-phosphate	14

Abbreviations: FDR, false discovery rate; PLS-DA, partial least square-discriminant analysis; SAM, significance analysis of microarrays (and metabolites); VIP, variable importance in projection.

N=5 mice per group and time point.