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Calibration of the model to match the total anti-PCSK9, total PCSK9, and LDLc reduction data from the phase I clinical study for RG7652 (results shown for three dose groups: 150, 300, and 800 mg); blue: individual clinical subjects; red: mean and 10–90 percentile range for virtual subjects. LDLc, low density lipoprotein cholesterol.
