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. 2014 Nov 26;3(11):e149. doi: 10.1038/psp.2014.47

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Copyright © 2014 American Society for Clinical Pharmacology and Therapeutics

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Model validation against phase I clinical data. LDLc lowering (% of baseline: calculated relative to the LDLc at time of first anti-PCSK9 dose) in response to multiple dose anti-PCSK9 as monotherapy and in combination with atorvastatin; (a) 40 mg anti-PCSK9, (b) 40 mg anti-PCSK9 + atorvastatin, (c) 150 mg anti-PCSK9, (d) 150 mg anti-PCSK9 + atorvastatin. Blue: individual clinical subjects; red: mean and 10–90 percentile range for virtual subjects. LDLc, low density lipoprotein cholesterol.