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Effect of statin background on response to anti-PCSK9. Response to single dose of 800 mg anti-PCSK9 for subjects on statin background (blue) and statin naïve subjects (red). (a) Total anti-PCSK9 and (b) LDLc. Solid lines show median predictions and dashed lines indicate the 10–90 percentile range. LDLc, low density lipoprotein cholesterol.
