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LOESS (locally weighted scatterpoint smoothing) non-linear regression modelling demonstrated that between an SP% of 11–25%, the CRC detection rate remained ∼4%. Above an SP% of 25%, every 10-percentage points increase was associated with a 2.5% increase in cancer. The vertical line drawn at an SP% of 22%, corresponds to the positivity pattern 4NN (created by four positive spots in kit one and normal results for kits two and three) a pattern not currently referred to colonoscopy.
