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. 2014 Nov 4;111(11):2103–2113. doi: 10.1038/bjc.2014.534

Figure 4.

Figure 4

DUSP1-mediated regulation of ERK 1/2 phosphorylation regulates sensitivity to MK-2206. (A) Cells transfected with control (ctrl) or DUSP1-directed siRNA oligonucleotides were treated with indicated concentrations of MK-2206 for 1 h in the respective cell lines. ‘+' indicates present and ‘−' indicates absent. (B) Transfected cells were treated with 1000 nM of MK-2206 for a further 72 h and the number of viable cells was assessed. Graphs indicate mean viable cell counts +/−s.e. expressed as a percentage of control and represent at least three independent experiments. Statistical comparison was performed using the student t-test (* indicates P<0.05).