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. 2014 Nov 4;111(11):2103–2113. doi: 10.1038/bjc.2014.534

Figure 7.

Figure 7

HD mutant PIK3CA confers sensitivity to MK-2206 in vivo. (A) Tumours from indicated cell lines were harvested and weighed after MK-2206 or control treatment. (B) Representative images from tumours, which were analysed with IHC using the indicated antibodies. Scale bar=20 μM. (C) RT112 tumours transfected with either control vector or mutant PIK3CA E545K were harvested after control or MK-2206 treatment and weighed. For all graphs, each dot indicates a data point and line indicates the mean. Statistical comparison was performed using the student t-test (* indicates P<0.05). All results are representative of at least two independent experiments.