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Dosing scheme and pharmacokinetic parameters of tirasemtiv (Part B).
| Dose (mg) | Cmax (µg/ml) | C24h (µg/ml) | AUC24h (h/µg/ml) | tmax (h) |
|---|---|---|---|---|
| 250 | 7.11 ± 1.71 | 2.43 ± 1.26 | 98.7 ± 36.1 | 3.50 ± 0.91 |
| 500 | 10.6 ± 2.85 | 4.86 ± 2.22 | 170 ± 53.5 | 4.08 ± 2.07 |
| 1000 | 16.0 ± 4.14 | 9.54 ± 3.26 | 282 ± 83.6 | 5.25 ± 3.11 |
Data expressed as mean ± SEM.
