Table 3.

Reported adverse events (Part B).

	Distinct subjects [n (%)]
Adverse event	Placebo (n = 12)	250 mg (n = 12)	500 mg (n = 12)	1000 mg (n = 12)	Overall (n = 12)
Euphoric mood	0 (0.0%)	3 (25.0%)	6 (50.0%)	7 (58.3%)	10 (83.3%)
Dizziness	1 (8.3%)	1 (8.3%)	4 (33.3%)	6 (50.0%)	9 (75.0%)
Somnolence	2 (16.7%)	3 (25.0%)	3 (25.0%)	3 (25.0%)	6 (50.0%)
Headache	2 (16.7%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	2 (16.7%)
Nausea	0 (0.0%)	0 (0.0%)	0 (0.0%)	1 (8.3%)	1 (8.3%)
Pharyngitis	0 (0.0%)	0 (0.0%)	0 (0.0%)	1 (8.3%)	1 (8.3%)
Muscle spasms	0 (0.0%)	0 (0.0%)	0 (0.0%)	1 (8.3%)	1 (8.3%)
Rhinorrhea	0 (0.0%)	0 (0.0%)	1 (8.3%)	0 (0.0%)	1 (8.3%)
Contact dermatitis	0 (0.0%)	0 (0.0%)	1 (8.3%)	1 (8.3%)	1 (8.3%)