Table 2.

Bleeding outcomes from the ARISTOTLE study for different bleeding definitions

Bleeding outcomes in ARISTOTLE
Type of	Apixaban event	Warfarin event	HR (apixaban/)
bleeding	rate (% per year)	rate (% per year)	(warfarin)	95% CI	P value
ISTH major	2.13	3.09	0.69	(0.60–0.80)	<0.0001
ISTH major/CRNM	4.07	6.01	0.68	(0.61–0.75)	<0.0001
TIMI major	0.96	1.69	0.57	(0.46–0.70)	<0.0001
GUSTO severe	0.52	1.13	0.46	(0.35–0.60)	<0.0001
Intracranial	0.33	0.80	0.42	(0.30–0.58)	<0.0001
Fatal	0.06	0.24	0.27	(0.13–0.53)	0.0002

Note that as the severity of the bleeding outcome increases, the hazard ratio of apixaban to warfarin decreases, indicating a favorable trend for safety.²⁹