Table 2.
Summary of differential gene expression by functional group in frontal and mid-coronal sections of 16- and 21-week-old SHRSP and WKY rats, performed using Ingenuity Pathway Analysis (see Table 1 for similar analysis of differentially expressed genes at 5 weeks)
| Frontal | Mid-coronal | |||
|---|---|---|---|---|
| Number of molecules | P-value | Number of molecules | P-value | |
| 16 weeks | ||||
| Diseases and disorders | ||||
| Inflammatory response | 4 | 7.68E-05–4.99E-02 | 6 | 7.68E-05–2.86E-02 |
| Neurological disease | 22 | 1.01E-03–4.61E-02 | 18 | 5.06E-05–3.91E-02 |
| Connective tissue disorders | 12 | 1.77E-03–2.86E-02 | NA | NA |
| Inflammatory disease | 15 | 1.77E-03–4.99E-02 | NA | NA |
| Skeletal and muscular disorders | 14 | 1.77E-03–2.86E-02 | NA | NA |
| Psychological disorders | NA | NA | 8 | 5.06E-05–7.23E-03 |
| Infectious disease | NA | NA | 7 | 1.38E-04–2.86E-02 |
| Cardiovascular disease | NA | NA | 6 | 5.68E-04–1.89E-02 |
| Molecular and cellular functions | ||||
| Amino acid metabolism | 6 | 7.68E-05–4.61E-02 | 4 | 7.68E-05–3.56E-02 |
| Drug metabolism | 4 | 7.68E-05–2.12E-02 | 4 | 7.68E-05–3.56E-02 |
| Molecular transport | 11 | 7.68E-05–4.95E-02 | 17 | 7.68E-05–4.26E-02 |
| Small molecule biochemistry | 16 | 7.68E-05–4.95E-02 | 19 | 7.68E-05–4.61E-02 |
| Cell death | 22 | 3.10E-03–4.61E-02 | NA | NA |
| Nucleic acid metabolism | NA | NA | 6 | 3.19E-04–4.61E-02 |
| 21 weeks | ||||
| Diseases and disorders | ||||
| Neurological disease | 39 | 5.83E-08–2.19E-02 | 31 | 2.49E-07–2.06E-02 |
| Skeletal and muscular disorders | 40 | 6.18E-07–2.19E-02 | 29 | 2.49E-07–1.29E-02 |
| Hereditary disorder | 34 | 7.50E-06–2.19E-02 | 27 | 2.49E-07–1.50E-02 |
| Cardiovascular disease | 15 | 1.61E-04–2.19E-02 | NA | NA |
| Developmental disorder | 19 | 3.20E-04–2.19E-02 | 14 | 1.13E-04–2.06E-02 |
| Inflammatory response | NA | NA | 10 | 1.01E-04–2.06E-02 |
| Molecular and cellular functions | ||||
| Cell-to-cell signalling and interaction | 28 | 5.52E-06–2.19E-02 | NA | NA |
| Cell cycle | 9 | 5.38E-05–1.68E-02 | NA | NA |
| Cellular assembly and organization | 28 | 5.38E-05–2.19E-02 | NA | NA |
| Cellular function and maintenance | 39 | 1.61E-04–2.12E-02 | NA | NA |
| Cell death | 45 | 3.40E-04–2.19E-02 | NA | NA |
| Amino acid metabolism | NA | NA | 6 | 7.98E-06–2.06E-02 |
| Small molecule biochemistry | NA | NA | 21 | 7.98E-06–2.41E-02 |
| Cell signalling | NA | NA | 11 | 5.79E-05–2.06E-02 |
| Molecular transport | NA | NA | 22 | 5.79E-05–2.41E-02 |
| Vitamin and mineral metabolism | NA | NA | 13 | 5.79E-05–2.18E-02 |
NA, not applicable.