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. Author manuscript; available in PMC: 2015 Oct 1.
Published in final edited form as: Mutat Res Rev Mutat Res. 2014 May 28;0:52–64. doi: 10.1016/j.mrrev.2014.05.001

Figure 3. Nonsense Suppression Therapy.

Figure 3

PTC-bearing mRNA transcripts that are not recognized and degraded by NMD will mature and produce truncated proteins that have deleterious effects on the cell. Read-through compounds will bind to either the 40S or 60S subunit of the ribosome and decrease the fidelity of the PTC. The purpose of nonsense suppression therapy is to trick the ribosome into accepting near-cognate aminoacyl-tRNAs into the A-site, therefore enhancing natural PTC read-through and increasing the abundance of full-length protein.