Table 1.
Induction of gene mRNA expression in HepG2 cells transfected with TLR4 expression vectors
| Symbols of genes | Description of the genes | Fold regulation |
|---|---|---|
| ABL1 | C-abl oncogen 1, non-receptor tyrosine kinase | 1.56 |
| APEX1 | APEX nuclease (multifunctional DNA repair enzyme) 1 | 1.86 |
| ATM | Ataxia telangiectasia mutated | 1.91 |
| ATR | Ataxia telangiectasia and Rad3 related | 1.42 |
| BRCA1 | Breast cancer 1, early onset | 1.23 |
| CHEK2 | CHK2 checkpoint homolog (S.pombe) | 1.41 |
| CIDEA | Cell death-inducing DFFA-like effector a | 1.32 |
| GADD45A | Growth arrest and DNA-damage inducible, alpha | 1.77 |
| GML | Glycosylphosphatidylinositol anchored molecule like protein | 1.3 |
| IP6K3 | Inositol hexaphosphate kinase 3 | 2.23 |
| MAPK6 | Mitogen-activated protein kinase 6 | 1.34 |
| MBD4 | Methyl-CpG binding domain protein 4 | 1.65 |
| BTG2 | B-cell translocation gene 2 | 1.43 |
| RAD18 | RAD18 homolog (S. cerevisiae) | 1.34 |
| RAD21 | RAD21 homolog (S. pombe) | 1.39 |
| SMC1A | Structural maintenance of chromosomes 1A | 1.62 |
| PNKP | Polynucleotide kinase 3′-phosphate | 1.27 |
Cells exposed to 10 μg/ml TiO2 NPs for 48 h prior to gene expression analysis with PCR array. Fold regulation values greater than 1 indicate positive regulation (up-regulation).