Table 1.
Minimum inhibitory concentrations and MIC ranges of cystic fibrosis respiratory pathogens versus cysteamine
| Bacteria (n = 103) | Median MIC 100 (μg/ml) | Range (μg/ml) |
|---|---|---|
| P. aeruginosa (n = 42) | 250 | 250-500 |
| P. fluorescens (n = 2) | 250-500 | 250-500 |
| P. putida (n = 1) | 250 | NA |
| B. cepacia (n = 3) | 250 | 250-500 |
| B. cenocepacia (n = 3) | 500 | 500-1000 |
| B. multivorans (n = 3) | 500 | 500 |
| Ach. xylosidans (n = 7) | 500 | 250-500 |
| Ach. denitrificans (n = 1) | 500 | NA |
| Al. faecalis (n = 2) | 250-500 | 250-500 |
| C. indologenes (n = 2) | 250-500 | |
| K. pneumoniae (n = 3) | 250 | 250-1000 |
| Pan. apista (n = 1) | 500 | NA |
| Pan. pnomenusa (n = 1) | 1000 | NA |
| R. pickettii (n = 3) | 500 | 500-1000 |
| R. mannitolilytica (n = 1) | 500 | NA |
| Sph. paucimobilis (n = 2) | 1000 | 1000 |
| St. maltophilia (n = 7) | 500 | 250-1000 |
| S. aureus (n = 14) | 250 | 250-500 |
Data are median MIC100 of triplicate samples in experiments repeated 3 times. P = Pseudomonas, B = Burkholderia, Ach = Achromobacter, Al = Alcaligenes, C = Chryseomonas, K = Klebsiella, Pan = Pandoraea, R = Ralstonia, Sph = Sphingomonas, St = Stenotrophomonas, S = Staphylococcus, NA = Not applicable.