Table 3. Peak Associations with Total Serum IgE Compared with Peak Associations with Asthma*.
| Chromosome | Gene† | Marker | Position‡ | P Value, Random Effects§ | |
|---|---|---|---|---|---|
| IgE | Asthma | ||||
| Loci linked to serum IgE | |||||
|
| |||||
| 1 | FCER1A | rs2252226 | 157542777 | 6.6×10−5 | 4.7×10−1 |
|
| |||||
| 5 | IL13 | rs20541 | 132023863 | 1.0×10−6 | 2.8×10−7 |
|
| |||||
| 6 | HLA-DRB1 | rs9271300 | 32689560 | 8.3×10−15 | 3.2×10−1 |
|
| |||||
| 12 | STAT6 | rs167769 | 55790042 | 8.5×10−7 | 7.2×10−4 |
|
| |||||
| 16 | IL4-R/IL21R | rs1859308 | 27305499 | 8.2×10−6 | 3.5×10−1 |
|
| |||||
| Loci linked to asthma | |||||
|
| |||||
| 2 | IL18R1 | rs3771166 | 102352654 | 2.0×10−1 | 3.4×10−9 |
|
| |||||
| 6 | HLA-DQB1 | rs9273349 | 32733847 | 5.4×10−5 | 7.0×10−14 |
|
| |||||
| 9 | IL33 | rs1342326 | 6180076 | 6.0×10−1 | 9.2×10−10 |
|
| |||||
| 15 | SMAD3 | rs744910 | 65233839 | 1.5×10−1 | 3.9×10−9 |
|
| |||||
| 17 | GSDMB | rs2305480 | 35315722 | 6.0×10−2 | 9.6×10−8 |
|
| |||||
| 17 | GSDM1 | rs3894194 | 35375519 | 3.0×10−1 | 4.6×10−9 |
|
| |||||
| 22 | IL2RB | rs2284033 | 35863980 | 3.9×10−1 | 1.1×10−8 |
|
| |||||
| 5 | IL13 | rs1295686 | 132023742 | 2.4×10−6 | 1.4×10−7 |
|
| |||||
| 5 | SLC22A5 | rs2073643 | 131751187 | 2.0×10−2 | 2.2×10−7 |
|
| |||||
| 15 | RORA | rs11071559 | 58857280 | 3.0×10−2 | 1.1×10−7 |
*
Two sets of loci are shown: the most significant hits that show association with the total serum IgE level (on the basis of genomewide-association-study significance in the current study or previously published studies) and those that show association with asthma in the current study.
†
The nominal gene was taken from the Illumina SNP database.
‡
Position is based on the number of base pairs from the start of the chromosome.
§
P values are shown for the association of marker with phenotype in a random effects model.