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Effect of URB596 on endogenous levels of AEA, OEA and PEA.
| Analyte | Brain region | Vehicle | URB597 (0.3 mg/kg) |
|---|---|---|---|
| AEA (nmol/g tissue) | Hippocampus | 37.9±20.5 | 59.7±9.4⁎ |
| Entorhinal cortex | 43.3±12.0 | 44.0±12.4 | |
| OEA (nmol/g tissue) | Hippocampus | 82.9±11.4 | 477.2±90.2⁎⁎ |
| Entorhinal cortex | 171.5±146.6 | 300.1±56.0⁎⁎ | |
| PEA (nmol/g tissue) | Hippocampus | 155.7±60.1 | 1691.8±377.6⁎⁎ |
| Entorhinal cortex | 85.7±50.0 | 917.6±195.8⁎⁎ | |
Values are given as mean±SD.
p<0.05.
p<0.001 compared to respective vehicle group.
