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. Author manuscript; available in PMC: 2014 Dec 9.
Published in final edited form as: Microbe Wash DC. 2012;7(8):353–359. doi: 10.1128/microbe.7.353.1

FIGURE 1.

FIGURE 1

C-di-GMP is synthesized by GGDEF enzymes possessing diguanylate cyclase (DGC) activity and degraded by EAL and HD-GYP enzymes possessing phosphodiesterase (PDE) activity. EAL enzymes cleave one bond of the cyclic structure generating the linear molecule pGpG while HD-GYP enzymes cleave both bonds to generate GMP. Many bacterial behaviors in addition to biofilm formation and motility are regulated, both positively and negatively, by c-di-GMP.