Fig. 1.

Schematic diagrams depicting dendritic shrinkage and expansion in response to chronic stress and recovery. Top: chronic stress leads to dendritic shrinkage in layer 3 pyramidal neurons in the prelimbic and anterior cingulate cortex, whereas it causes dendritic expansion in the corresponding neurons within orbitofrontal cortex. Both effects are seen primarily in the distal apical dendritic tree. Bottom: while shrinkage and recovery both affect distal dendrites in neurons depicted in the top panel, layer 5 neurons in infralimbic cortex lose distal dendritic branches in response to stress, yet recovery occurs primarily in proximal dendrites, shifting the dendritic architecture (see (Goldwater et al., 2009)). Reprinted from (McEwen and Morrison, 2013) by permission.