Table 4.

The Association between Complications of Prematurity and Neonatal TSH

	Mean TSH (mIU/L)±SD	r2	1 P-value	r2	2 P-value
Bronchopulmonary dysplasia N=500		0.035	<0.0001	0.059	0.29
No (N=355)	5.9±3.9
Yes (N=145)	4.6±3.3
Intraventricular hemorrhage N=450		0.003	0.26	0.052	0.52
No (N=396)	5.4±3.6
Yes (N=54)	4.6±2.4
Necrotizing enterocolitis N=618		0.001	0.43	0.054	0.77
No (N=606)	5.7±3.7
Yes (N=12)	5.0±3.4
Patent ductus arteriosus N=678		0.027	<0.0001	0.062	0.08
No (N=557)	6.0±3.7
Yes (N=121)	4.6±3.3
Periventricular leukomalacia N=556		0.005	0.08	0.056	0.17
No (N=547)	5.6±3.7
Yes (N=9)	3.6±1.9
Respiratory distress syndrome N=607		0.084	<0.0001	0.103	<0.0001
No (N=247)	6.7±3.9
Yes (N=360)	4.8±3.2
Retinopathy of prematurity N=504		0.017	3x10−3*	0.060	0.43
No (N=431)	5.7±3.8
Yes (N=73)	4.2±2.3
Sepsis N=583		0.057	<0.0001	0.080	3x10−3
No (N=190)	6.7±3.8
Suspected (N=314)	5.4±3.7
Yes (N=79)	4.5±3.0
APGAR score at 1 minute N=688		0.003	0.13	0.058	0.54
<5 (N=138)	5.4±3.7
≥5 (N=550)	5.9±3.7
APGAR score at 5 minutes N=689		0.001	0.32	0.059	0.79
<5 (N=21)	5.2±3.5
≥5 (N=668)	5.8±3.7
Highest direct bilirubin at birth N=186		0.069	4x10−3	0.110	0.06
<25th (0–0.2) (N=21)	5.8±4.8
25–50th (0.3) (N=56)	6.9±4.0
50–75th (0.4–0.7) (N=61)	5.4±2.9
>75th (0.8–18.6) (N=48)	4.4±2.6
Highest total bilirubin at birth N=654		0.007	0.20	0.062	0.35
<25th (0.8–7.3) (N=157)	5.4±3.8
25–50th (7.4–9.2) (N=161)	5.4±3.4
50–75th (9.3–11.4) (N=174)	6.1±4.1
>75th (11.5–27.1) (N=162)	5.8±3.4
Hemoglobin at birth* N=306		0.018	0.14	0.075	0.63
<25th (10.2–15.5) (N=75)	5.2±3.4
25–50th (15.6–17) (N=82)	5.3±3.3
50–75th (17.1–18.4) (N=72)	5.9±3.4
>75th (18.6–25.5) (N=77)	6.3±4.1

¹P-value: single variable one-way ANOVA.

²P-value: ANOVA adjusted for gestational age.

^*Bartlett’s test for equal variances was p=0.002.