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Crk alignments based on NCBI sequences by using the Clustal Omega program from the European bioinformatics institute (EMBL-EBI) (http://www.ebi.ac.uk/Tools/msa/clustalo/). (a) SH2 domains. Note the PRR in CrkII. (b) nSH3 domains. (c) Linker region containing the regulatory tyrosines (indicated by an asterisk). (d) cSH3 domains. Note the low homology of mouse CrkII.
