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Extent of acylation inhibition (%) afforded by divalent cations
| Time (days) |
Formulation # | |||
|---|---|---|---|---|
| 5 | 6 | 7 | 8 | |
| 7 | 68.5±2.4 | 69.1±1.3 | 73.7±3.8 | 74.2±2.6 |
| 14 | 53.6±1.3 | 61.5±4.1 | 62.0±2.5 | 65.7±3.7 |
| 21 | 53.2±3.8 | 53.3±3.1 | 62.7±0.8 | 70.9±3.6 |
| 28 | 37.3±3.7 | 40.5±2.2 | 57.8±2.0 | 61.4±3.0 |
Inhibition extent was calculated by [acylated octreotide content in microspheres without additive(%) – acylated octreotide content in microsphere with salt additive(%)]/acylated octreotide content in microspheres without additive(%)
