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. Author manuscript; available in PMC: 2015 Sep 1.
Published in final edited form as: Alcohol Clin Exp Res. 2014 Sep;38(9):2468–2478. doi: 10.1111/acer.12515

Figure 5.

Figure 5

Tolcapone suppresses ethanol intake and drinking behavior in the 2CAP protocol. In sucrose animals, Tolcapone (17 mg/kg) suppresses sucrose consumption in P rats with no effect in Wistars (A1). No changes in time at sipper were detected in sucrose animals after Tolcapone (A2). Tolcapone (30 mg/kg) suppresses ethanol consumption in P rats with no effects observed in Wistars (B1). Both doses of Tolcapone decrease time spent at the sipper in P rats (B2). A median spilt was performed in each group of animals and it was observed that 30 mg/kg Tolcapone suppressed drinking in each of the high drinking subgroups while the 17 mg/kg dose only suppressed ethanol consumption in high-drinking animals (C). No measureable effect on ethanol consumption after AMPH injection was observed in a group of ethanol reinforced P rats (D). * p<0.05, ** p<0.01 Bonferroni corrected planned comparison.