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. 2014 Dec 4;8:281–291. doi: 10.2147/BTT.S57619

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© 2014 Jasim et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License

The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

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A simplified illustration about the intracellular pathways and mechanisms of action for select small-molecule kinase inhibitors in differentiated thyroid carcinoma.

Abbreviations: Sor, sorafenib; Sun, sunitinib; Len, lenvatinib; Paz, pazopanib; Mot, motesanib; Axi, axitinib; Vem, vemurafenib; Dab, dabrafenib; VEGFR, vascular endothelial growth factor receptor; FGFR, fibroblast growth factor receptor; RET/PTC, rearranged during transfection/papillary thyroid carcinoma; PI3K, phosphatidylinositol-3 kinase; mTOR, mammalian target of rapamycin.