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Schematic of NanoFlare structure and function. The NanoFlare contains a monolayer of antisense DNA (recognition sequence) adsorbed to the surface of a 13-nm spherical gold nanoparticle. A reporter flare sequence is hybridized to the recognition sequence, which contains a fluorophore (red). The dye is quenched in close proximity to the gold surface. The reporter flare is displaced when complementary mRNA (blue) binds the recognition sequence, providing a fluorescent signal.
