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. Author manuscript; available in PMC: 2015 Apr 8.
Published in final edited form as: Cell Host Microbe. 2014 Sep 25;16(4):495–503. doi: 10.1016/j.chom.2014.09.001

Figure 1. Tryptamine production by C. sporogenes.

Figure 1

(A) The proteinogenic amino acid L-tryptophan is decarboxylated to tryptamine, a biogenic amine neurotransmitter, by the action of pyridoxal phosphate (PLP)-dependent decarboxylases. (B) Whole C. sporogenes were grown anaerobically in minimal media containing 5 g/L tryptophan, and clarified supernatant was analyzed by HPLC. C. sporogenes converts tryptophan (12.5 min) into tryptamine (TAM, 10.5 min), indole lactic acid (ILA, 22 min), and indole propionic acid (28 min). See also Figure S1 and S5.