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. 1998 Dec 14;28(8):2549–2558. doi: 10.1002/(SICI)1521-4141(199808)28:08<2549::AID-IMMU2549>3.0.CO;2-O

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© 1998 WILEY-VCH Verlag GmbH, Weinheim, Fed. Rep. of Germany

Re-use of this article is permitted in accordance with the Creative Commons Deed, Attribution 2.5, which does not permit commercial exploitation.

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Rescue of immature but not mature self-reactive B cells from sHEL/anti-HEL double Tg donors. FACS analysis of B220⁺ spleen cells obtained from sHEL Tg recipients of mature (a–f) or immature (g–l) B cells at 1 (a, b, g, h), 3 (c, d, i, j) and 5 (e, f, k, l) days after transfer. The majority of recipient CFSE⁻ cells were excluded from collection to increase the sensitivity of detection of CFSE⁺ donor-derived cells. Undivided (dotted rectangles) and divided (rectangles with heavy borders) HEL-binding B cells are indicated. In addition, the proportion of surviving undivided donor-derived B cells that have down-regulated HEL-binding (rectangles with fine borders) is increased by T cell help, a phenomenon that is also apparent in vitro (not shown).