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. Author manuscript; available in PMC: 2015 Oct 1.
Published in final edited form as: DNA Repair (Amst). 2014 Aug 9;22:77–88. doi: 10.1016/j.dnarep.2014.07.003

Fig. 4.

Fig. 4

Domain organization of selected X-family DNA polymerases. Mammalian DNA polymerase β is composed of two domains that complement its biological role in base excision repair: lyase (purple) and polymerase (light blue and green). The polymerase domain includes three subdomains: catalytic (C, green) and nucleotide binding (N, green) and DNA binding (D, light blue). DNA polymerase μ, Tdt, pol λ and Pol IV have an amino-terminal BRCT domain (light red). The two bacterial enzymes include a carboxyl-terminal PHP/HIS2 domain (pink) connected to the polymerase domain with a linker (yellow). Pol λ includes a serine-proline-rich region (S/P-rich, orange).