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. 2014 Nov 6;5(11):e1507. doi: 10.1038/cddis.2014.451

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Copyright © 2014 Macmillan Publishers Limited

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International Licence. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons licence, users will need to obtain permission from the licence holder to reproduce the material. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0

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TIS-T cells modulate monocytes/macrophages through Tim-3/Gal-9 and CD40L/CD40 pathways. Monocytes were cultured with CD4+ or CD8+ TIS-T cells in the presence of blocking mAb against Tim-3 or CD40L molecules or IgG1κ isotype control. After 40 h LPS was added and 48 h later cytokines and angiogenic factors were measured. Cytokine and angiogenic factors production in CD4+ TIS-T/Mo-Ma (a) and CD8+ TIS-T/Mo-Ma (b) co-cultures, in the presence of isotype control paired to blocking mAb. Statistical analysis was performed by using Wilcoxon signed rank test. P-values (TIS-T/Mo-Ma co-cultures with IgG1κ isotype control versus TIS-T/Mo-Ma co-cultures with blocking mAb) are indicated on graphs