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. 2014 Nov 6;5(11):e1511. doi: 10.1038/cddis.2014.469

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Copyright © 2014 Macmillan Publishers Limited

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International Licence. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons licence, users will need to obtain permission from the licence holder to reproduce the material. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/

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The time-dependent effect of mitochondrial ETC complex III inhibition on the expression of ATF4 and its target genes in HCT116 cells. (a–f) The effects of myxothiazol (1 μM) for indicated intervals of time on ATF4, CHOP, TRIB3, SLC7A11, CHAC1 and TP53INP1 mRNA levels in HCT116 cells were examined by RT-qPCR. Mean and S.D. are presented of three independent experiments. All values are normalized to the level of the corresponding mRNA in the control (untreated) cells. (g) Western analysis of p53 in myxothiazol-treated HCT116 cells for indicated intervals of time