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Proposed model showing how DHA reduces the expression of the E6/E7 viral oncoproteins in oncogenic HPV-infected cancer cells. DHA stimulates cellular ROS accumulation primarily via inducing mitochondrial ROS overproduction, which leads to mitochondria failure and the activation of cellular UPS. As a result, the UPS-dependent degradation of E6/E7 viral proteins is accelerated. Note that mitochondrial dysfunction might contribute to the UPS activation induced by DHA (dashed line)
