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. 2014 Nov 20;5(11):e1528. doi: 10.1038/cddis.2014.479

Figure 1.

Figure 1

Increased VSOR Cl− currents in tunicamycin exposed cardiomyocytes. (a) Negligible background Cl− currents recorded under isosmotic solution (Ctrl). Tm (3 μg/ml)-induced Cl− currents exhibiting representative properties of VSOR Cl− currents (Tm). Tm-induced VSOR Cl− currents were inhibited by adding DIDS (500 μM); n=5 for each group. (b) Corresponding current-voltage (I-V) relationship for the mean current densities of Ctrl (▴), Tm (▪) and Tm with DIDS (●) conditions. (c) Current densities at +100 mV from b. *P<0.05 versus Ctrl; **P<0.05 versus Tm, n=5. (d) Negligible background Cl− currents recorded under isosmotic solution (Ctrl). Tm (3 μg/ml)-induced Cl− currents exhibiting representative properties of VSOR Cl− currents (Tm). Tm-induced VSOR Cl− currents were inhibited by adding DCPIB (10 μM); n=5 for each group. (e) Corresponding current-voltage (I-V) relationship for the mean current densities of Ctrl (▴), Tm (▪) and Tm with DCPIB (●) conditions. (f) Current densities at +100 mV from (e). *P<0.05 versus Ctrl; **P<0.05 versus Tm, n=5