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. 2014 Nov 20;5(11):e1528. doi: 10.1038/cddis.2014.479

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Copyright © 2014 Macmillan Publishers Limited

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International Licence. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons licence, users will need to obtain permission from the licence holder to reproduce the material. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0

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ROS production mediates tunicamycin induced VSOR Cl⁻ currents. (a) Background Cl⁻ currents recorded under isosmotic solution (Ctrl). Tm (3 μg/ml)-induced VSOR Cl⁻ currents exhibiting phenotypic properties of I_Cl,Vol (Tm). Tm-induced VSOR Cl⁻ currents were inhibited by the ROS scavenger NAC (10 mM). n=5 for each group. (b) Corresponding current-voltage (I-V) relationship for the mean current densities of isosmotic (▴), Tm (▪) and Tm with NAC (●) conditions. (c) Current densities at +100 mV from (b). *P<0.05 versus Ctrl; **P<0.05 versus Tm, n=5