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. 2014 Nov 20;5(11):e1536. doi: 10.1038/cddis.2014.500

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Copyright © 2014 Macmillan Publishers Limited

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International Licence. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons licence, users will need to obtain permission from the licence holder to reproduce the material. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0

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Combination simvastatin and metformin treatment induces significant, sustained G1-phase cell cycle arrest in C4-2B metastatic CRPC cells. C4-2B3 and C4-2B4 cells were treated with 4 μM simvastatin (SIM) and 2 mM metformin (MET) for 24−96 h followed by staining with propidium iodide and analysis by flow cytometry. Percentage of cells (mean±S.D.) in G1, S, and G2/M phases of the cell cycle and sub-G1 represented in bar graphs, n=3 per treatment group. Significance of G1-phase cell cycle arrest, where *P<0.05, **P<0.01, ***P<0.001, determined by ANOVA followed by the Tukey multiple comparison procedure where a=untreated, b=SIM, c=MET, and d=SIM+MET in comparisons