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. Author manuscript; available in PMC: 2015 Jun 1.
Published in final edited form as: Nat Neurosci. 2014 Nov 2;17(12):1673–1681. doi: 10.1038/nn.3858

Figure 2.

Figure 2

No paranodal or axonal abnormalities were observed in sciatic nerves of AnkB-cKO mice. (a–l) Immunostaining of sciatic nerve longitudinal sections from 4 to 6-week-old (a–i, l), P3 (j, AnkB, N105/17) and 1-year-old (k) mice shows normal paranodal and juxtaparanodal domains and proper Nav channel subtype switch in AnkB-cKO mice. NFasc, neurofascin (both nodal 186-kDa and paranodal 155-kDa isoforms were stained). Cntn, contactin. βIV, βIV spectrin. ZO-1, zona occludens protein 1. MAG, myelin-associated glycoprotein. CNP, 2′,3′-cyclic nucleotide 3′ phosphodiesterase. Necl4, nectin-like protein 4. Two mice per genotype and more than 75 (j) or 150 (a–i, k, l) nodes were examined in each mouse. Scale bars = 5 μm (a, b; c–g; h; i; j; k; l).