Table 2. Description of 26 shared-types (SITs; n = 137 isolates) and corresponding spoligotyping defined lineages/sublineages starting from a total of 227 cryopreserved M. tuberculosis strains isolated from adults with pulmonary tuberculosis in Lima, Peru.
SIT | Spoligotype Description | Octal Number | Nb in this study | % in study | % in this study vs. database | Lineage** | Match with a strain from (for newly created SITs)*** | Unique vs. Clustered¥ |
1 | □□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□▪▪▪▪▪▪▪▪▪ | 000000000003771 | 13 | 9.15 | 0.13 | Beijing | Clustered | |
42 | ▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪□□□□▪▪▪▪▪▪▪▪□□□□▪▪▪▪▪▪▪ | 777777607760771 | 4 | 2.82 | 0.12 | LAM9 | Clustered | |
47 | ▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪□□□□□□▪□□□□▪▪▪▪▪▪▪ | 777777774020771 | 16 | 11.27 | 1.07 | H1 | Clustered | |
49 | ▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪□▪□□□□▪▪▪□▪▪▪ | 777777777720731 | 4 | 2.82 | 2.26 | H3 | Clustered | |
50 | ▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪□▪□□□□▪▪▪▪▪▪▪ | 777777777720771 | 21 | 14.79 | 0.63 | H3 | Clustered | |
52 | ▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪□□□□▪▪▪□▪▪▪ | 777777777760731 | 3 | 2.11 | 0.33 | T2 | Clustered | |
53 | ▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪□□□□▪▪▪▪▪▪▪ | 777777777760771 | 7 | 4.93 | 0.12 | T1 | Clustered | |
91 | ▪▪▪□□□□□□□□□□▪▪▪▪□▪▪▪▪▪▪▪▪▪▪▪▪▪▪□□□□▪▪▪▪▪▪▪ | 700036777760771 | 1 | 0.7 | 0.4 | X3 | Unique | |
93 | ▪▪▪▪▪▪▪▪▪▪▪▪□▪▪▪▪▪▪▪□□□□▪▪▪▪▪▪▪▪□□□□▪▪▪▪▪▪▪ | 777737607760771 | 3 | 2.11 | 0.84 | LAM5 | Clustered | |
189 | ▪▪▪▪▪▪▪▪▪▪▪▪▪□□□□▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪□□□□▪▪▪▪▪▪▪ | 777741777760771 | 1 | 0.7 | 9.09 | T1 | Unique | |
219 | ▪▪▪▪▪▪▪▪▪▪▪▪▪□□□□□▪▪▪▪▪▪▪▪▪▪▪▪▪▪□□□□▪▪▪▪▪▪▪ | 777740777760771 | 21 | 14.79 | 35.59 | T1 | Clustered | |
222 | ▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪□□□□□▪▪▪▪▪▪▪□▪▪▪□□□□▪▪▪▪▪▪▪ | 777774077560771 | 1 | 0.7 | 1.89 | Unknown | Unique | |
291 | ▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪□▪▪▪▪▪▪▪▪▪▪▪□□□□▪▪▪▪▪▪▪ | 777777677760771 | 1 | 0.7 | 1.15 | T1 | Unique | |
469 | □□□▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪□□□□▪▪▪▪▪▪▪▪□□□□▪▪▪▪▪▪▪ | 077777607760771 | 5 | 3.52 | 14.71 | LAM1 | Clustered | |
1122 | ▪▪▪▪▪□▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪□□□□▪▪▪▪▪▪▪ | 767777777760771 | 1 | 0.7 | 1.69 | T1 | Unique | |
1160 | ▪▪▪▪▪▪▪▪▪▪▪▪□▪▪▪▪▪□▪□□□□▪▪▪▪▪▪▪▪□□□□▪▪▪▪▪▪▪ | 777737207760771 | 1 | 0.7 | 25 | LAM5 | Unique | |
1355 | ▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪□□□□□▪▪▪▪□▪▪▪□□□□▪▪▪□▪▪▪ | 777777407560731 | 7 | 4.93 | 12.73 | LAM | Clustered | |
1905 | ▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪□□▪▪□□□□▪▪▪▪▪▪▪ | 777777777460771 | 2 | 1.41 | 9.52 | T1 | Clustered | |
2375 | ▪▪▪▪▪□▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪□□□□□□▪□□□□▪▪▪▪▪▪▪ | 767777774020771 | 2 | 1.41 | 15.38 | H1 | Clustered | |
2502 | ▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪□□□□□▪▪▪▪□▪▪▪□□□□▪▪▪▪▪▪▪ | 777777407560771 | 2 | 1.41 | 40 | LAM6 | Clustered | |
2940 | ▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪□□□□▪▪▪▪▪▪▪▪□□□□▪□□▪▪▪▪ | 777777607760471 | 1 | 0.7 | 14.29 | LAM9 | Unique | |
3001 | ▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪□□□□□▪▪▪▪▪▪□□□□▪□□□□▪▪▪▪▪▪▪ | 777774077020771 | 11 | 7.75 | 55 | H3 | Clustered | |
3777 | ▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪□▪□□□▪▪▪▪▪▪▪□▪▪▪□□□□▪▪▪▪▪▪▪ | 777775077560771 | 1 | 0.7 | 50 | T1 | This study (n = 1), ESP (n = 1) | Unique |
3778 | ▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪□▪□□□▪▪▪▪▪▪□□□□▪□□□□▪▪▪▪▪▪▪ | 777775077020771 | 5 | 3.52 | 100 | H3 | This study (n = 5) | Clustered |
3779 | ▪▪▪▪▪□▪▪▪▪▪▪▪▪▪▪□□□□□▪▪▪▪▪▪□□□□▪□□□□▪▪▪▪▪▪▪ | 767774077020771 | 2 | 1.41 | 100 | H3 | This study (n = 2) | Clustered |
3780 | ▪▪▪□□□□□□□□□□▪▪▪▪□▪▪▪▪▪▪▪▪▪▪▪▪▪□□□□□▪▪▪▪▪▪▪ | 700036777740771 | 1 | 0.7 | 50 | X3 | This study (n = 1), PER (n = 1) | Unique |
*A total of 22/26 SITs (n = 128) matched a preexisting shared-type in the database, whereas 4/26 SITs (n = 9 isolates) were newly created either within the present study or after a match with an orphan in the database.
A total of 17 SITs containing 128 isolates were clustered within this study (2 to 21 isolates per cluster), while 9 SITs contained a unique strain within this study. Note that SITs in bold indicates “newly created shared-type” (n = 4 containing 9 isolates) due to 2 or more strains belonging to an identical new pattern within this study or after a match with an orphan in the database.
**Lineage designations according to SITVIT2; “Unknown” designates patterns with signatures that do not belong to any of the major clades described in the database.
*** SIT designations are indicated in the table.
ESP = Spain, PER = Peru.
Clustered strains correspond to a similar spoligotype pattern shared by 2 or more strains “within this study”; as opposed to unique strains harboring a spoligotype pattern that does not match with another strain from this study.