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. 2014 Dec 9;9(12):e112789. doi: 10.1371/journal.pone.0112789

Table 2. Description of 26 shared-types (SITs; n = 137 isolates) and corresponding spoligotyping defined lineages/sublineages starting from a total of 227 cryopreserved M. tuberculosis strains isolated from adults with pulmonary tuberculosis in Lima, Peru.

SIT Spoligotype Description Octal Number Nb in this study % in study % in this study vs. database Lineage** Match with a strain from (for newly created SITs)*** Unique vs. Clustered¥
1 □□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□□▪▪▪▪▪▪▪▪▪ 000000000003771 13 9.15 0.13 Beijing Clustered
42 ▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪□□□□▪▪▪▪▪▪▪▪□□□□▪▪▪▪▪▪▪ 777777607760771 4 2.82 0.12 LAM9 Clustered
47 ▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪□□□□□□▪□□□□▪▪▪▪▪▪▪ 777777774020771 16 11.27 1.07 H1 Clustered
49 ▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪□▪□□□□▪▪▪□▪▪▪ 777777777720731 4 2.82 2.26 H3 Clustered
50 ▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪□▪□□□□▪▪▪▪▪▪▪ 777777777720771 21 14.79 0.63 H3 Clustered
52 ▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪□□□□▪▪▪□▪▪▪ 777777777760731 3 2.11 0.33 T2 Clustered
53 ▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪□□□□▪▪▪▪▪▪▪ 777777777760771 7 4.93 0.12 T1 Clustered
91 ▪▪▪□□□□□□□□□□▪▪▪▪□▪▪▪▪▪▪▪▪▪▪▪▪▪▪□□□□▪▪▪▪▪▪▪ 700036777760771 1 0.7 0.4 X3 Unique
93 ▪▪▪▪▪▪▪▪▪▪▪▪□▪▪▪▪▪▪▪□□□□▪▪▪▪▪▪▪▪□□□□▪▪▪▪▪▪▪ 777737607760771 3 2.11 0.84 LAM5 Clustered
189 ▪▪▪▪▪▪▪▪▪▪▪▪▪□□□□▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪□□□□▪▪▪▪▪▪▪ 777741777760771 1 0.7 9.09 T1 Unique
219 ▪▪▪▪▪▪▪▪▪▪▪▪▪□□□□□▪▪▪▪▪▪▪▪▪▪▪▪▪▪□□□□▪▪▪▪▪▪▪ 777740777760771 21 14.79 35.59 T1 Clustered
222 ▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪□□□□□▪▪▪▪▪▪▪□▪▪▪□□□□▪▪▪▪▪▪▪ 777774077560771 1 0.7 1.89 Unknown Unique
291 ▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪□▪▪▪▪▪▪▪▪▪▪▪□□□□▪▪▪▪▪▪▪ 777777677760771 1 0.7 1.15 T1 Unique
469 □□□▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪□□□□▪▪▪▪▪▪▪▪□□□□▪▪▪▪▪▪▪ 077777607760771 5 3.52 14.71 LAM1 Clustered
1122 ▪▪▪▪▪□▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪□□□□▪▪▪▪▪▪▪ 767777777760771 1 0.7 1.69 T1 Unique
1160 ▪▪▪▪▪▪▪▪▪▪▪▪□▪▪▪▪▪□▪□□□□▪▪▪▪▪▪▪▪□□□□▪▪▪▪▪▪▪ 777737207760771 1 0.7 25 LAM5 Unique
1355 ▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪□□□□□▪▪▪▪□▪▪▪□□□□▪▪▪□▪▪▪ 777777407560731 7 4.93 12.73 LAM Clustered
1905 ▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪□□▪▪□□□□▪▪▪▪▪▪▪ 777777777460771 2 1.41 9.52 T1 Clustered
2375 ▪▪▪▪▪□▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪□□□□□□▪□□□□▪▪▪▪▪▪▪ 767777774020771 2 1.41 15.38 H1 Clustered
2502 ▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪□□□□□▪▪▪▪□▪▪▪□□□□▪▪▪▪▪▪▪ 777777407560771 2 1.41 40 LAM6 Clustered
2940 ▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪□□□□▪▪▪▪▪▪▪▪□□□□▪□□▪▪▪▪ 777777607760471 1 0.7 14.29 LAM9 Unique
3001 ▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪□□□□□▪▪▪▪▪▪□□□□▪□□□□▪▪▪▪▪▪▪ 777774077020771 11 7.75 55 H3 Clustered
3777 ▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪□▪□□□▪▪▪▪▪▪▪□▪▪▪□□□□▪▪▪▪▪▪▪ 777775077560771 1 0.7 50 T1 This study (n = 1), ESP (n = 1) Unique
3778 ▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪▪□▪□□□▪▪▪▪▪▪□□□□▪□□□□▪▪▪▪▪▪▪ 777775077020771 5 3.52 100 H3 This study (n = 5) Clustered
3779 ▪▪▪▪▪□▪▪▪▪▪▪▪▪▪▪□□□□□▪▪▪▪▪▪□□□□▪□□□□▪▪▪▪▪▪▪ 767774077020771 2 1.41 100 H3 This study (n = 2) Clustered
3780 ▪▪▪□□□□□□□□□□▪▪▪▪□▪▪▪▪▪▪▪▪▪▪▪▪▪□□□□□▪▪▪▪▪▪▪ 700036777740771 1 0.7 50 X3 This study (n = 1), PER (n = 1) Unique

*A total of 22/26 SITs (n = 128) matched a preexisting shared-type in the database, whereas 4/26 SITs (n = 9 isolates) were newly created either within the present study or after a match with an orphan in the database.

A total of 17 SITs containing 128 isolates were clustered within this study (2 to 21 isolates per cluster), while 9 SITs contained a unique strain within this study. Note that SITs in bold indicates “newly created shared-type” (n = 4 containing 9 isolates) due to 2 or more strains belonging to an identical new pattern within this study or after a match with an orphan in the database.

**Lineage designations according to SITVIT2; “Unknown” designates patterns with signatures that do not belong to any of the major clades described in the database.

*** SIT designations are indicated in the table.

ESP = Spain, PER = Peru.

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Clustered strains correspond to a similar spoligotype pattern shared by 2 or more strains “within this study”; as opposed to unique strains harboring a spoligotype pattern that does not match with another strain from this study.