Figure 5. Correspondence between causal effect estimates and cross-sectional associations of BMI with systemic metabolites.

Causal effect estimates based on Mendelian randomization are plotted against the metabolite associations with observed BMI based a cross-sectional study design. The orange dashed line denotes the linear fit of the correspondence. Darker dots indicate statistical differences between causal effect estimates and cross-sectional association magnitudes. The gray shaded areas serve to guide the eye for the slope of correspondence. BP, blood pressure; PUFA, polyunsaturated fatty acid; SHBG, sex hormone–binding globulin.