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. 2014 Dec 9;9(12):e114533. doi: 10.1371/journal.pone.0114533

Table 3. GO processes and pathways most strongly enriched by meta-signature miRNA targets.

Pathway enrichment analysis FDR Targets
GO process
GO:0006355: regulation of transcription, DNA-dependent (BP) 3.34324E-13 39
GO:0007165: signal transduction (BP) 3.77687E-13 42
GO:0045944: positive regulation of transcription from RNA polymerase II promoter (BP) 1.84064E-11 22
GO:0051301: cell division (BP) 1.13136E-10 19
GO:0044419: interspecies interaction between organisms (BP) 1.67014E-10 20
GO:0007049: cell cycle (BP) 3.92822E-09 21
GO:0007399: nervous system development (BP) 5.35901E-09 12
GO:0007156: homophilic cell adhesion (BP) 8.576E-09 8
GO:0030154: cell differentiation (BP) 1.00415E-08 22
GO:0008285: negative regulation of cell proliferation (BP) 1.15719E-08 18
KEGG pathway
Kegg:05200: Pathways in cancer 1.85246E-11 21
Kegg:04722: Neurotrophin signaling pathway 4.02366E-10 13
Kegg:04310: Wnt signaling pathway 3.9198E-09 13
Kegg:04510: Focal adhesion 1.10106E-07 13
Kegg:04115: p53 signaling pathway 3.36014E-07 8
Kegg:04110: Cell cycle 4.83318E-07 10
Kegg:05212: Pancreatic cancer 5.06487E-07 8
Kegg:05220: Chronic myeloid leukemia 7.02671E-07 8
Kegg:04120: Ubiquitin mediated proteolysis 1.1415E-06 10
Kegg:05221: Acute myeloid leukemia 1.61649E-06 7
Panther pathway
Panther:P00057: Wnt signaling pathway 5.18994E-10 18
Panther:P00021: FGF signaling pathway 1.24487E-08 11
Panther:P00053: T cell activation 8.93741E-08 9
Panther:P00010: B cell activation 2.05044E-06 7
Panther:P00012: Cadherin signaling pathway 4.86842E-06 6
Panther:P00031: Inflammation mediated by chemokine and cytokine signaling pathway 5.58894E-06 11
Panther:P00047: PDGF signaling pathway 9.10927E-06 6
Panther:P00013: Cell cycle 1.13184E-05 3
Panther:P00012: Cadherin signaling pathway 1.16394E-05 9
Panther:P00005: Angiogenesis 0.000016605 6