Figure 4. Correlations between the changes in neutrophil spontaneous migration score (NAS_N) and the timing of sepsis in burn patients.

(A) Neutrophil activation score averages are significantly different between burn patients with sepsis (N = 21) and patients with SIRS (N = 29, P = 0.038) or patients with no SIRS (N = 21, P = 0.027). (B) The NAS_N is significantly higher in patients in samples before clinical diagnosis (P = 0.036) and drops to one third following septic diagnosis and post-antibiotic therapy. (C) ROC curves for averaged NAS_N of two successive blood samples demonstrates the good predictive values of the spontaneous neutrophil migration patterns for sepsis in patients with major burns.